Fighting antimicrobial resistance
First-in-kind approach to explore bacterial pathogen
Using a first-in-kind One Health detection and analysis approach, we are exploring the presence, persistence, and transmission of Kp and related AMR within and across human, animal, and environmental reservoirs. The project will provide a foundation for
- further development of global surveillance methodology to monitor the flow of Kp and related AMR across sectors
- the development of whole metagenomic sequencing beyond the state-of-art for diagnostics and surveillance of Kp-clonal lineages involved in AMR dispersion and pathogenicity, and
- pre-clinical efficacy studies of bacteriophages as treatment of colonisation and infection by multidrug-resistant (MDR) Kp.
Benefitting from unique surveillance infrastructure
The project takes advantage of the unique Norwegian human and animal AMR-surveillance infrastructure, the Institute of Marine Research/ Norwegian Food Safety Authority sampling systems in the marine environment, the interdisciplinary AMR One Health Norwegian Kp-network (NOR-KLEB-NET), and the ongoing Norwegian human Kp-study (NOR-KLEB) to access animal, human, and environmental Kp-reservoirs/-strains/-genomes with relevant metadata.
The project involves six Norwegian and four international partners. The Norwegian institutions are cross-sectorial and include university hospitals, institutes, a university, and one industry partner.