Fighting antimicrobial resistance


The KLEB-GAP project aims to provide new, timely insights into the ecology, antimicrobial resistance (AMR), and pathogenicity of Klebsiella pneumoniae (Kp), a WHO high-priority bacterial pathogen in the fight against AMR. The project runs its simulations on national supercomputer Saga.

Close up of microbes.

First-in-kind approach to explore bacterial pathogen

Using a first-in-kind One Health detection and analysis approach, the KLEB-GAP researchers are exploring the presence, persistence, and transmission of Kp and related AMR within and across human, animal, and environmental reservoirs.

"With the help of the national e-infrastructure resources provided by Sigma2, we aim to extend our knowledge of human and animal Kp-ecology.

We also analyse strain-level Kp-diversity in metagenomes, and disclose gut microbiome composition patterns that may support or exclude Kp-colonization."

Arnfinn Sundsfjord, Professor of Medical Microbiology, UiT

The project will provide a foundation for:

  • further development of global surveillance methodology to monitor the flow of Kp and related AMR across sectors.

  • the development of whole metagenomic sequencing beyond the state-of-art for diagnostics and surveillance of Kp-clonal lineages involved in AMR dispersion and pathogenicity, and

  • pre-clinical efficacy studies of bacteriophages as treatment of colonisation and infection by multidrug-resistant (MDR) Kp.

Benefitting from unique surveillance infrastructure

The project takes advantage of the unique Norwegian human and animal AMR-surveillance infrastructure, the Institute of Marine Research/ Norwegian Food Safety Authority sampling systems in the marine environment, the interdisciplinary AMR One Health Norwegian Kp-network (NOR-KLEB-NET), and the ongoing Norwegian human Kp-study (NOR-KLEB) to access animal, human, and environmental Kp-reservoirs/-strains/-genomes with relevant metadata.

Kenneth Lindstedt, Dorota Buczek and Arnfinn Sundsfjord.
Kenneth Lindstedt, PhD-student, Dorota Buczek, Postdoc and Arnfinn Sundsfjord, Professor from UiT – The Arctic University of Norway.